Generation of Nickel Siloxycarbene Complexes from Acylsilanes for the Catalytic Synthesis of Silyl Enol Ethers

2024/11/25 by Akihisa Matsuura, Yuri Ito, Tetsuya Inagaki +2 · 1 voice
Chemistry · #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods #Cyclopropane Reaction Mechanisms

paper · doi:10.1021/acscatal.4c06272

openalex publication_date 2024/11/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/13

Abstract

A catalytic protocol has been developed to access Fischer carbene nickel complexes using acylsilanes as stable and readily available precursors. The as-generated Fischer carbene complexes exhibit versatile reactivity, including cyclopropanation with alkenes, α-C–H insertion reactions, and two-component C–H addition to norbornene, which demonstrates the broad utility of the nickel(0)/acylsilane system for the catalytic applications of Fischer carbene complexes.

Discussions

• #RobSelects paper of the week #ACSCatalysis: Nickel-catalyzed activation of acylsilanes via Fischer carbene nickel complexes. #catalysis https://doi.org/10.1021/acscatal.4c06272 [bsky, 3 points, 0 comments]

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