2024/09/14 by Sarah Koch, Sandra Márquez, José Urquiza +12 · 1 voice
Medicine · #Human Health and Disease
paper · doi:10.1183/13993003.congress-2024.pa3122
openalex publication_date 2024/09/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
<bold>Introduction:</bold> Inhaled dose, the product of inspired air and air pollution concentration is a novel approach to study the combined health impacts of physical activity and air pollution. We compared the effects of weekly moderate-to-vigorous physical activity (MVPA), nitrogen dioxide (NO<sub>2</sub>) and particulate matter (PM<sub>2.5</sub>) concentrations, and inhaled dose (IDNO<sub>2</sub> and IDPM<sub>2.5</sub>) on lung function. <bold>Methods:</bold> Forced expiratory volume in one second (%FEV<sub>1</sub>) and forced vital capacity (%FVC) were measured in 1581 children (838 boys) aged 8.2±1.6 years in the Human Early Life Exposome (HELIX) study. Children’s MVPA was calculated from questionnaires. The NO<sub>2</sub> and PM<sub>2.5</sub> exposures the week prior to spirometry were estimated using land use regression modelling. IDNO<sub>2</sub> and IDPM<sub>2.5</sub> were calculated as the product of pol concentration and estimated minute ventilation from MVPA. Using linear regressions, we assessed the main effects of MVPA, pollutant concentrations, IDs, and the interaction effects of MVPA and air pollution exposures on %FEV<sub>1</sub> and %FVC. <bold>Results & Discussion:</bold> MVPA appears to positively affect %FEV<sub>1</sub> and %FVC in children, even when accounting for NO<sub>2</sub> or PM<sub>2.5</sub> exposure concentrations. The effects of IDNO<sub>2</sub> and IDPM<sub>2.5</sub> on lung function were similar to those for the main effects of MVPA with adjustment for the pollutant. No interaction effects between MVPA and either NO<sub>2</sub> or PM<sub>2.5</sub> exposure, respectively, were found.