2019/08/16 by Paras K. Mishra, Adriana Adameová, Joseph A. Hill +12 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #Mitochondrial Function and Pathology #Viral Infections and Immunology Research
paper · pdf · doi:10.1152/ajpheart.00259.2019
openalex publication_date 2019/08/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed multiple forms of cell death, and several of them have been demonstrated to underlie adverse cardiac remodeling and heart failure. With the expansion in the area of myocardial cell death and increasing concerns over rigor and reproducibility, it is important and timely to set a guideline for the best practices of evaluating myocardial cell death. There are six major forms of regulated cell death observed in cardiac pathologies, namely apoptosis, necroptosis, mitochondrial-mediated necrosis, pyroptosis, ferroptosis, and autophagic cell death. In this article, we describe the best methods to identify, measure, and evaluate these modes of myocardial cell death. In addition, we discuss the limitations of currently practiced myocardial cell death mechanisms.