2010/10/29 by Jae Min Kim, Robert Stewart, Seon‐Young Kim +5 · 1 voice
Medicine · #Alzheimer's disease research and treatments #Cardiac Health and Mental Health #Dementia and Cognitive Impairment Research
paper · doi:10.1002/gps.2621
openalex publication_date 2010/10/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21
OBJECTIVES: A cohort study of Japanese-American men suggested interactive effects of depression and apolipoprotein E (APOE) e4 allele on risk of incident dementia. In another sample of East Asian origin, we sought to replicate the findings and to explore individual depressive symptoms where this interaction was most evident. METHODS: Of 625 Korean community elders without dementia at baseline, 518 (83%) were followed over a 2.4-year period and were clinically assessed for incident dementia. Depression was identified by the Geriatric Mental State Schedule (GMS), and nine individual depressive symptoms relevant to DSM-IV major depressive episode criteria were extracted. APOE genotype was ascertained. Covariates included age, gender, education, and disability. RESULTS: There were synergistic interactions between depression and APOE e4 on incident dementia independent of covariates. This interaction was particularly strong for four depressive symptoms: depressed mood, worthlessness, concentration difficulty, and suicidal ideation. CONCLUSIONS: We were able to replicate the previous study, finding that, at least in East Asian origin populations, the APOE e4 allele is a stronger predictor of incident dementia in the presence of depressive syndrome, and particular depressive symptoms.