2025/04/04 by Tia Rudman, Richard S. Rowlands, Jørgen Skov Jensen +2 · 1 voice
Immunology and Microbiology · Medicine · #Blood groups and transfusion #Herpesvirus Infections and Treatments #Microbial infections and disease research
paper · doi:10.1099/jmm.0.001984
openalex publication_date 2025/04/04 · openalex created_date 2025/04/05 · openalex updated_date 2026/07/15
Graphical abstract Mycoplasma genitalium infections are enabled by multiple virulence factors, both intracellular and expressed on the cholesterol-containing phospholipid membrane. Intracellular accessory proteins form the tip structure, which adheres to epithelial cells in vivo via the transmembrane adhesion complex of Nap proteins, P110 and P140. Protein M binds to the Fab region of immunoglobulins with a high affinity to both λ and κ chains, enabling immune system evasion. Membrane lipoproteins and extracellular polymeric substances help in biofilm formation, which is thought to facilitate infection persistence.