2001/12/01 by M T De Sanctis, M.T. De Sanctis, L. Incandela +4
Medicine · #Diagnosis and Treatment of Venous Diseases #Peripheral Artery Disease Management #Venous Thromboembolism Diagnosis and Management
paper · doi:10.1177/0003319701052003s07
crossref issued 2001/12/01 · crossref published 2001/12/01 · crossref published-online 2001/12/01 · crossref published-print 2001/12/01 · openalex publication_date 2001/12/01 · openalex created_date 2016/06/24 · crossref created 2017/01/06 · crossref deposited 2026/04/28 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31
The involvement of the microcirculation in chronic venous insufficiency (CVI), due to venous hypertension, causes venous hypertensive microangiopathy (VHM) and ulceration. VHM is characterized by enlarged, convoluted capillaries; microvascular thrombosis; obliteration of some capillaries; increase in flux, permeability, and edema and altered microlymphatics. PO2 is decreased and CO2 increased. Capillary exchanges are altered and nutritional alterations eventually lead to venous ulcers. Edema is associated with increased capillary pressure, reduced clearance, and increased exchange surface of capillaries, which become tortuous and glomerular-like. The aim of this randomized, placebo-controlled study was to evaluate local treatment with Essaven gel (EG) in subjects with venous microangiopathy and ulcers. Measurements of laser Doppler flux, PO2, and PCO2 in standardized conditions showed positive changes (a significant decrease of the abnormally increased flux and CO2 while PO2 increased) in the EG treatment group. Changes in the placebo and control group were more limited (changes in the placebo group were mainly associated with skin manipulation when placebo-EG was applied). In conclusion, Essaven gel, in comparison with placebo, acutely improves the microcirculation in VHM even with a single acute application.