2019/06/24 by Benjamin Nilsson Wadström, Abd-al Hakim Fatehali, Gunnar Engström +1
paper · doi:10.1177/0003319719857270
crossref issued 2019/06/24 · crossref published 2019/06/24 · crossref published-online 2019/06/24 · crossref created 2019/06/25 · crossref published-print 2019/11/01 · crossref deposited 2026/04/28 · crossref indexed 2026/07/31
The morphology and function of the arteries can be directly measured using different established methods. This prospective cohort study aimed to translate 2 of these, aortic pulse wave velocity (aPWV) and carotid intima–media thickness (cIMT), into a combined Vascular Aging Index (VAI) and then evaluate the predictive power of aPWV, cIMT, and VAI. Patients (n = 2718) were included from the cardiovascular arm of the Malmö Diet and Cancer Study (median age 71.9 years, 62.2% females). Total follow-up time was 16 448 person-years and a composite cardiovascular disease (CVD) end point was used. Cox regressions yielded adjusted hazard ratios (95% confidence interval) per 1 standard deviation increment of log e aPWV, log e cIMT, and log e VAI of 1.25 (1.08-1.45, P = .003), 1.27 (1.13-1.44, P