2024/12/13 by Sabrina Champsi, David A. Hood · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · #Biochemical Acid Research Studies #Coenzyme Q10 studies and effects #Genomics, phytochemicals, and oxidative stress
paper · doi:10.1152/ajpcell.00669.2024
openalex publication_date 2024/12/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Nrf-2 is a transcription factor that has been implicated in mitigating oxidative stress and regulating mitochondrial homeostasis. However, limited research has demonstrated how Nrf-2-mediated adaptations compare with those produced by exercise. To investigate this, we treated myotubes with Sulforaphane, a well-established Nrf-2 activator, and combined this with stimulation-induced chronic contractile activity to model exercise training. Our work is the first to establish that sulforaphane mimics training-induced mitochondrial adaptations, including enhancements in respiration, biogenesis, and dynamics.