The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation

2025/08/04 by Isak K. Aarrestad, Lindsay P. Cameron, Ethan M. Fenton +41 · 1 voice · 1 citation
Chemistry · Psychology · #Chemical synthesis and alkaloids #Psychedelics and Drug Studies

paper · doi:10.1038/s41593-025-02021-1

crossref issued 2025/08/04 · crossref published 2025/08/04 · crossref published-online 2025/08/04 · openalex publication_date 2025/08/04 · crossref created 2025/08/04 · crossref published-print 2025/09/01 · crossref deposited 2025/09/04 · openalex created_date 2025/10/10 · crossref indexed 2026/07/23 · openalex updated_date 2026/07/23

Citations

• Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
• Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder
• Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
• SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data
• Trial of Psilocybin versus Escitalopram for Depression
• Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action
• Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
• Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
• A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
• Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential

Cited by

• <i>R</i> -MDDMA is a Safer Analogue of MDMA with Therapeutic Potential

Discussions

• "Our work challenges the hypothesis that #psychedelics promote neuroplasticity by inducing a glutamate burst." Hmm, if something like TBG is effective as a neuroplastogen, I can potentially see it bec [bsky, 3 points, 1 comments]