Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states

2025/11/04 by Nikolai P. Jaschke, Nikolai Jaschke, Joseph R. Luchsinger +13 · 1 voice
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Genetics, Aging, and Longevity in Model Organisms #Ion Channels and Receptors #Regulation of Appetite and Obesity

paper · doi:10.1016/j.cell.2025.10.005

openalex publication_date 2025/11/04 · openalex created_date 2025/11/04 · crossref created 2025/11/04 · crossref issued 2025/12/01 · crossref published 2025/12/01 · crossref published-print 2025/12/01 · crossref deposited 2026/05/13 · openalex updated_date 2026/07/08 · crossref indexed 2026/07/13

Citations

• The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial

Discussions

• Gut enterochromaffin cells detect ammonia from amino acid breakdown via the wasabi receptor TRPA1, triggering serotonin release to the brain. This serves as a first-line defense against ammonia toxici [bsky, 3 points, 0 comments]