Solid-state conformations of pharmaceutical polymorphs in solution: validation and invalidation by NMR.

2026/01/01 by Kirthi Joshi, Shruti Sangwan, K. V. Jovan Jose +2 · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Advanced NMR Techniques and Applications #Crystallography and molecular interactions #Drug Solubulity and Delivery Systems

paper · doi:10.1039/d5ce01120e

openalex publication_date 2026/01/01 · openalex created_date 2026/01/17 · openalex updated_date 2026/07/08

Abstract

Polymorphs 1a, 1b, 1c reported by Kumar et al. were reinvestigated by validated solution and solid-state NMR, X-ray diffraction, and computations to show that the 3 polymorphs do not retain their distinct conformational identity in solution.

Citations

• Solid-state NMR spectroscopy

Discussions

• The latest inside front cover features work by Vipin Agarwal, Ashwini K. Nangia & co-workers investigating solid-state conformations of pharmaceutical polymorphs in solution: validation and invalidati [bsky, 3 points, 1 comments]

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