2026/03/01 by Kelly de Korodi, Tatiana V. Petrova · 1 voice
Medicine · #Lymphatic System and Diseases #Lymphatic Disorders and Treatments #Vascular Malformations and Hemangiomas
paper · doi:10.1172/jci203656
openalex publication_date 2026/03/01 · openalex created_date 2026/03/01 · openalex updated_date 2026/07/12
Although transcriptional programs driving lymphatic endothelial cell (LEC) specification are being increasingly characterized, far less is known about the postnatal mechanisms that preserve lymphatic vessel identity and function. In this issue of the JCI, Yang et al. show that the E26 transformation-specific (ETS) transcription factors ETS-related gene (Erg) and Friend leukemia integration 1 (Fli1) cooperatively maintain adult LEC homeostasis by sustaining transcriptionally distinct LEC populations, vascular integrity, immune-vascular interactions, and repression of proinflammatory and prothrombotic gene programs. These findings extend the known roles of Erg and Fli1 beyond the blood endothelium and provide mechanistic insight into human lymphatic disease associated with Erg haploinsufficiency.