2024/04/26 by Maxwell L. Elliott, Jared A. Nielsen, Lindsay C. Hanford +8 · 1 voice
Neuroscience · Medicine · #Functional Brain Connectivity Studies #Advanced Neuroimaging Techniques and Applications #Advanced MRI Techniques and Applications
paper · pdf · doi:10.1162/imag_a_00175
openalex publication_date 2024/04/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
-weighted scans (~1 minute) that achieve morphometric errors that are close to the errors in longer traditional scans. As acceleration allows multiple scans to be acquired in rapid succession, it becomes possible to pool estimates to increase measurement precision, a strategy known as "cluster scanning." Here, we explored brain morphometry using cluster scanning in a test-retest study of 40 individuals (12 younger adults, 18 cognitively unimpaired older adults, and 10 adults diagnosed with mild cognitive impairment or Alzheimer's Dementia). Morphometric errors from a single compressed sensing (CS) 1.0 mm scan (CS) were, on average, 12% larger than a traditional scan using the Alzheimer's Disease Neuroimaging Initiative (ADNI) protocol. Pooled estimates from four clustered CS acquisitions led to errors that were 34% smaller than ADNI despite having a shorter total acquisition time. Given a fixed amount of time, a gain in measurement precision can thus be achieved by acquiring multiple rapid scans instead of a single traditional scan. Errors were further reduced when estimates were pooled from eight CS scans (51% smaller than ADNI). Neither pooling across a break nor pooling across multiple scans of different spatial resolutions boosted this benefit. We discuss the potential of cluster scanning to improve morphometric precision, boost statistical power, and produce more sensitive disease progression biomarkers.