Sinus mast cell accumulation and persistence suggest a unique endotype in toxin exposure–associated chronic rhinosinusitis

2026/02/10 by Xinyu Wang, Yung-An Huang, Anshika Sethi +15 · 1 voice
Medicine · Immunology and Microbiology · #Sinusitis and nasal conditions #Mast cells and histamine #Allergic Rhinitis and Sensitization

paper · pdf · doi:10.1172/jci201075

openalex publication_date 2026/02/10 · openalex created_date 2026/02/11 · openalex updated_date 2026/07/08

Abstract

This study identifies a toxin-associated chronic rhinosinusitis endotype, defined by persistent mast cell accumulation, advancing understanding of how environmental exposures may drive chronic airway disease.

Discussions

• This Research Letter advances our understanding for how environmental exposures may drive chronic airway disease: doi.org/10.1172/JCI2... Wang et al. @ucsdmedschool.bsky.social identify a toxin-assoc [bsky, 3 points, 1 comments]

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