2026/01/29 by V Chapman, C Hassell, G Orbell +1 · 1 voice
Veterinary · Immunology and Microbiology · Medicine · #Helminth infection and control #Parasites and Host Interactions #Parasitic Diseases Research and Treatment
paper · pdf · doi:10.1080/00480169.2026.2615096
openalex publication_date 2026/01/29 · openalex created_date 2026/01/30 · openalex updated_date 2026/07/31
AIMS: (liver fluke) present on a sheep and beef farm in New Zealand. MATERIALS AND METHODS: . Ewes were either left untreated as controls or treated with a single oral dose of either a combination of 0.2 mg/kg moxidectin and 10 mg/kg triclabendazole or 10 mg/kg triclabendazole alone, both at the manufacturer's recommended dose. At necropsy, 49 days later, livers were collected for total adult liver fluke counts. RESULTS: All ewes in the trial had live liver fluke (min 1, max 148 flukes/liver). The efficacy was 30% for moxidectin plus triclabendazole and 21% for triclabendazole alone, confirming triclabendazole resistance on this farm. CONCLUSION: This is the first reported case of triclabendazole-resistant liver fluke in New Zealand. CLINICAL RELEVANCE: The finding of triclabendazole-resistant liver fluke in New Zealand should alert farmers and veterinarians to consider triclabendazole resistance as a potential cause of treatment failure, and adapt the farm liver fluke management and treatment regimens. In addition, resistant fluke could be widespread around New Zealand due to livestock being sold from this farm.