The Rising Burden of Early-Onset Cancer: Challenges and Opportunities

2026/06/01 by Andrea Cercek, Daniel J. Zabransky, Gianluca Mauri +3 · 1 voice
Environmental Science · Medicine · #Acute Lymphoblastic Leukemia research #Birth, Development, and Health #Health, Environment, Cognitive Aging

paper · doi:10.1158/2159-8290.cd-26-0328

openalex publication_date 2026/06/01 · openalex created_date 2026/06/02 · openalex updated_date 2026/07/22

Abstract

Early-onset cancers are increasing globally, yet traditional research frameworks have yet to inform the epidemiologic and biological underpinnings of this trend. This perspective summarizes the current state of knowledge and prospects for a research agenda spanning epidemiology, exposure science, mechanistic studies, and federated infrastructures to address this emerging challenge.

Citations

• Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019
• Epigenetic memory of colitis promotes tumour growth

Discussions

• With both the EACR and AACR hosting conferences on Early Onset Cancers recently, the organisers joined together to co-author an article on this topic: The Rising Burden of Early-Onset Cancer: Challeng [bsky, 3 points, 0 comments]

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