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Sharing neurophysiology data from the Allen Brain Observatory

2023/06/28 by Saskia de Vries, Joshua H. Siegle, Christof Koch · 1 voice · 2 citations
Neuroscience · Medicine · #Functional Brain Connectivity Studies #Optical Imaging and Spectroscopy Techniques #Advanced MRI Techniques and Applications

paper · doi:10.7554/elife.85550

openalex publication_date 2023/06/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26

Abstract

Nullius in verba ('trust no one'), chosen as the motto of the Royal Society in 1660, implies that independently verifiable observations-rather than authoritative claims-are a defining feature of empirical science. As the complexity of modern scientific instrumentation has made exact replications prohibitive, sharing data is now essential for ensuring the trustworthiness of one's findings. While embraced in spirit by many, in practice open data sharing remains the exception in contemporary systems neuroscience. Here, we take stock of the Allen Brain Observatory, an effort to share data and metadata associated with surveys of neuronal activity in the visual system of laboratory mice. Data from these surveys have been used to produce new discoveries, to validate computational algorithms, and as a benchmark for comparison with other data, resulting in over 100 publications and preprints to date. We distill some of the lessons learned about open surveys and data reuse, including remaining barriers to data sharing and what might be done to address these.

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