From Chaos to Clarity? The Quest for Effective Probiotics in Antibiotic-Associated Diarrhea

2024/10/21 by Krishna Rao, Kevin W. Garey · 1 voice
Medicine · #Clostridium difficile and Clostridium perfringens research #Gastrointestinal motility and disorders #Microscopic Colitis

paper · pdf · doi:10.1093/ofid/ofae616

openalex publication_date 2024/10/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Antibiotic-associated diarrhea (AAD) frequently complicates treatment of infections. A recent randomized, double-blind, placebo-controlled trial tested a proprietary probiotic mixture and found that it reduced the incidence of AAD by 16%. This is encouraging for patients, but future progress on probiotics for AAD and other conditions depends on transparency around strain selection, probiotic design guided by preclinical mechanistic studies, and rigorously conducted human studies.

Citations

• Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
• Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults

Discussions

• The editorial was enlightening I tend to agree with the criticism. Why these strains and this combination? What’s the mechanism? Is it applicable in a more general sense? #IDsky doi.org/10.1093/ofid. [bsky, 4 points, 0 comments]

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