2015/11/30 by Matthew S. Robbins, Carrie E. Robertson, Eugene D. Kaplan +15 · 1 citation
Medicine · #Migraine and Headache Studies #Ophthalmology and Eye Disorders #Trigeminal Neuralgia and Treatments
paper · doi:10.1111/head.12729
crossref issued 2015/11/30 · crossref published 2015/11/30 · crossref published-online 2015/11/30 · openalex publication_date 2015/11/30 · crossref created 2015/11/30 · crossref published-print 2016/02/01 · openalex created_date 2025/10/10 · crossref deposited 2025/11/02 · crossref indexed 2026/07/29 · openalex updated_date 2026/07/30
The sphenopalatine ganglion (SPG) has attracted the interest of practitioners treating head and face pain for over a century because of its anatomical connections and role in the trigemino-autonomic reflex. In this review, we discuss the anatomy of the SPG, as well as what is known about its role in the pathophysiology of headache disorders, including cluster headache and migraine. We then address various therapies that target the SPG, including intranasal medication delivery, new SPG blocking catheter devices, neurostimulation, chemical neurolysis, and ablation procedures.