2002/06/28 by Beate C. Sydora, B C SYDORA, Norbert Wagner +11
Immunology and Microbiology · Medicine · #Cell Adhesion Molecules Research #Immunodeficiency and Autoimmune Disorders #Immunotherapy and Immune Responses
paper · doi:10.1046/j.1365-2249.2002.01892.x
crossref issued 2002/06/28 · crossref published 2002/06/28 · crossref published-online 2002/06/28 · crossref published-print 2002/06/28 · openalex publication_date 2002/06/28 · crossref created 2003/03/11 · openalex created_date 2016/06/24 · crossref deposited 2023/04/23 · openalex updated_date 2026/07/23 · crossref indexed 2026/07/30
beta7 Integrins have been shown to have an important role in the localization of T cells to the intestine. Utilizing two different experimental mouse models of inflammatory bowel disease (IBD), this study was undertaken to determine if beta7 integrin expression is critical for T cell localization to the intestine and colitis pathogenesis. Transfer of CD4+ CD45RBhigh cells into immunodeficient mice results in colitis. To examine the role of beta7 integrins, donor cells were obtained from beta7 integrin gene-deficient animals and disease induction was examined following transfer into severe combined immunodeficiency (SCID) mice. Additionally, beta7 integrin gene-deficient animals were crossed to IL-2-deficient mice and the onset of spontaneous colitis that normally occurs in IL-2-deficient animals was examined. No differences in the onset or severity of spontaneous colitis was noted in animals that were deficient in both beta7 integrin and IL-2. In contrast, the onset of colitis in recipients of T cells from beta7 integrin-deficient donors was delayed significantly. In mice receiving beta7 integrin negative cells, the initial lack of colitis appeared to correlate with fewer numbers of CD3+beta7 integrin -/- donor lymphocytes present in the host colon. The eventual development of disease, however, was associated with increased numbers of donor beta7 integrin -/- lymphocytes. These results show that beta7 integrin expression is not absolutely required for T cell localization to the intestine and colitis pathogenesis.