1981/07/01 by Kiran Kucheria, R. K. Kenue, R.K. Kenue +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Congenital limb and hand anomalies #Hedgehog Signaling Pathway Studies #Prenatal Screening and Diagnostics
paper · doi:10.1111/j.1399-0004.1981.tb01803.x
crossref issued 1981/07/01 · crossref published 1981/07/01 · crossref published-print 1981/07/01 · openalex publication_date 1981/07/01 · crossref published-online 2008/04/23 · crossref created 2010/07/18 · crossref deposited 2023/11/10 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/30
An Indian family was observed with postaxial polycactyly in four generations. Of the twelve affected cases, eleven were male and one was female. The affected males showed postaxial polydactyly Type A in both hands and feet. The affected female showed polysyndactyly and both Types A and B postaxial polydactyly. Study of this family strongly suggests a common causal factor for postaxial polydactyly Types A and B and polysyndactyly. The observations also support an autosomal dominant pattern of inheritance and a high degree of genetic heterogeneity in ths malformation.