1971/05/01 by David Bixler, P. Fogh‐Andersen, Poul Fogh‐Andersen +1
Biochemistry, Genetics and Molecular Biology · #Cleft Lip and Palate Research
paper · doi:10.1111/j.1399-0004.1971.tb00271.x
crossref issued 1971/05/01 · crossref published 1971/05/01 · crossref published-print 1971/05/01 · openalex publication_date 1971/05/01 · crossref published-online 2008/04/23 · crossref created 2010/07/18 · crossref deposited 2023/11/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28 · crossref indexed 2026/07/30
The results of this study support the idea that CL(P) is a polygenic trait. Furthermore, employing the calculations of Edwards, there was little evidence for major gene effects. The sex‐modified threshold concept which has been made an integral part of the CL(P) polygenic model was not entirely confirmed by these data. These data show an affected offspring risk for CP parents of both sexes of about 6 %. Although Edward's calculations failed to provide evidence for major gene effects in CP, there was an unexplained five‐fold difference between CP frequency in offspring and sibs which needs further study.