2014/12/16 by Cuong D. Tran, Joanna Hawkes, Robin D. Graham +4
paper · doi:10.1177/0009922814562665
crossref issued 2014/12/16 · crossref published 2014/12/16 · crossref published-online 2014/12/16 · crossref created 2014/12/18 · crossref published-print 2015/06/01 · crossref deposited 2026/04/28 · crossref indexed 2026/07/28
A randomized double-blind placebo-controlled study was conducted in children admitted to hospital with gastroenteritis (≥3 loose stools per day). All were treated for 5 days following admission with either zinc (Zn, 3 mg) or without Zn-fortified rice-based oral rehydration solution (ORS). 13 C-sucrose breath test (SBT) and intestinal permeability (lactulose/rhamnose or L/R ratio) were performed concurrently prior to commencement of ORS with or without Zn and at day 5 post-admission. There was a significant improvement in the SBT results in both the Zn-fortified group, median (5th-95th percentile) 2.1% (0.4% to 8.3%) versus 4.4% (0.4% to 10.4%), P