2015/11/01 by M. A. Savitskaya, G. E. Onishchenko, Г. Е. Онищенко
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #Endoplasmic Reticulum Stress and Disease #RNA regulation and disease
paper · doi:10.1134/s0006297915110012
crossref issued 2015/11/01 · crossref published 2015/11/01 · crossref published-print 2015/11/01 · openalex publication_date 2015/11/01 · crossref created 2015/11/18 · crossref published-online 2015/11/19 · openalex created_date 2025/10/10 · crossref deposited 2026/03/16 · crossref indexed 2026/07/29 · openalex updated_date 2026/07/31
Nearly 15 types of programmed cell death (PCD) have been identified to date. Among them, apoptosis is the most common and well-studied type of PCD. In this review, we discuss different apoptotic pathways in which plasma membrane and membrane organelles, such as mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and nucleus play the pivotal role. Data concerning caspase cascades involved in these mechanisms are described. Various apoptosis induction mechanisms are analyzed and compared. The close relations between them and the possibility of switching from one pathway to another are demonstrated. In most cases, the result of these pathways is mitochondrial membrane permeabilization and/or caspase activation. These two events are closely linked and serve as the central point of integration of the apoptotic cell death pathways.