Hypokalaemic paresis, hypertension, alkalosis and adrenal‐dependent hyperadrenocorticism in a dog

2008/03/19 by DR Davies, SF Foster, BJ Hopper +3

paper · doi:10.1111/j.1751-0813.2008.00276.x

crossref issued 2008/03/19 · crossref published 2008/03/19 · crossref published-online 2008/03/19 · crossref created 2008/03/20 · crossref published-print 2008/04/01 · crossref deposited 2023/10/12 · crossref indexed 2026/07/24

Abstract

Generalised paresis, severe hypokalaemia and kaliuresis, metabolic alkalosis and hypertension, characteristic of mineralocorticoid excess, were identified in a dog with hyperadrenocorticism due to a functional adrenocortical carcinoma. Aldosterone concentration was decreased and deoxycorticosterone concentration increased in the presence of hypokalaemia. These metabolic abnormalities resolved with resection of the carcinoma. Mineralocorticoid excess in dogs with hyperadrenocorticism is generally considered to be of little clinical significance but resulted in the acute presentation of this patient. The possible pathogenesis of mineralocorticoid excess in this case of canine hyperadrenocorticism is discussed.

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