Animal models of Mycobacterium abscessus pulmonary infection phenotypes: What are we modeling?

2025/08/11 by Xiangyu Sui, Stefan H. Oehlers · 1 voice
Medicine · Veterinary · #Infectious Diseases and Mycology #Mycobacterium research and diagnosis #Tuberculosis Research and Epidemiology

paper · pdf · doi:10.1371/journal.ppat.1013414

crossref issued 2025/08/11 · crossref published 2025/08/11 · crossref published-online 2025/08/11 · openalex publication_date 2025/08/11 · crossref created 2025/08/11 · crossref deposited 2025/08/11 · openalex created_date 2025/10/10 · crossref indexed 2026/02/20 · openalex updated_date 2026/07/31

Abstract

Pulmonary infections caused by Mycobacterium abscessus have been difficult to model as most wild-type mice rapidly clear infection across a range of inoculation routes.Existing animal models of M. abscessus infection can be broadly classified into acute overwhelming infection, self-limiting mucosal clearance, and chronic granulomatous pathologies.We will make the argument that each of these models potentially models distinct endotypes of M. abscessus infection and highlight opportunities to understand infection biology through comparison of experimental models.

Citations

• Transcriptional and cytokine signatures of Mycobacterium abscessus complex pulmonary disease during disease progression and treatment

Discussions

• A PEARL w/ @astar-idlabs.bsky.social PhD student Xiangyu Sui #IDsky #microsky #immunsky "Animal models of Mycobacterium abscessus pulmonary infection phenotypes: What are we modeling?" We propose Mabs [bsky, 4 points, 1 comments]