2025/09/15 by Aurélia Joly, Meghan Ferguson, Min‐Jeong Shin +1 · 1 voice
Immunology and Microbiology · #Aquaculture disease management and microbiota #Invertebrate Immune Response Mechanisms
paper · doi:10.1242/bio.062025
openalex publication_date 2025/09/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Immune signals coordinate the repair of damaged epithelia by intestinal stem cells. However, it is unclear if immune pathways act autonomously within the stem cell to direct the damage response pathway. We consider this an important question, as stem cell dynamics are essential for formation and maintenance of the entire epithelium. We used Drosophila to determine the impact of stem cell-specific loss of NF-κB on tissue regeneration upon chemical injury. We found that loss of NF-κB enhanced cell death, impaired enterocyte renewal and increased mortality. Mechanistically, we showed that inhibition of stem cell apoptosis is essential for NF-κB-dependent maintenance of cell viability and tissue repair. Combined, our data demonstrate that stem cell-intrinsic NF-κB activity is essential for an orderly repair of damaged intestinal epithelia.