Autoantibody hotspots reveal the origin and impact of immunogenic XIST ribonucleoprotein complexes in autoimmune diseases

2026/02/10 by Bingyu Yan, Jinwoo Lee, Suhas Srinivasan +15 · 2 voices · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Complement system in diseases #Diabetes and associated disorders #Systemic Lupus Erythematosus Research

paper · pdf · doi:10.1172/jci198291

openalex publication_date 2026/02/10 · openalex created_date 2026/02/11 · openalex updated_date 2026/07/30

Abstract

Novel autoantibodies target hotspots on the XIST ribonucleoprotein complex in female-biased autoimmune diseases.

Citations

• A large-scale binding and functional map of human RNA-binding proteins

Cited by

• XIST RNA-protein complex in female-biased autoimmunity: From molecular scaffolds to new clinical biomarkers

Discussions

• Autoimmune diseases affect nearly 50 million Americans & 4 of 5 are women doi.org/10.1172/JCI1... In this Research Letter, Howard Y. Chang @howardychang.bsky.social & team show autoantibodies target [bsky, 4 points, 0 comments]
• Autoimmune diseases affect nearly 50 million Americans, & 4 out of 5 patients are women: doi.org/10.1172/JCI1... In this Research Letter, ASCI member @howardychang.bsky.social & team show novel autoa [bsky, 1 points, 0 comments]

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