2022/02/25 by T. Tajnšek, Erik Svensson Grape, Tom Willhammar +5 · 1 voice
Chemistry · Materials Science · #Metal-Organic Frameworks: Synthesis and Applications #Crystallography and molecular interactions #X-ray Diffraction in Crystallography
paper · pdf · doi:10.1038/s42004-022-00639-x
openalex publication_date 2022/02/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
Bioapplication is an emerging field of metal-organic frameworks (MOF) utilization, but biocompatible MOFs with permanent porosity are still a rarity in the field. In addition, biocompatibility of MOF constituents is often overlooked when designing bioMOF systems, intended for drug delivery. Herein, we present the a Zn(II) bioMOF based on vitamin C as an independent ligand (bioNICS-1) forming a three-dimensional chiral framework with permanent microporosity. Comprehensive study of structure stability in biorelavant media in static and dynamic conditions demonstrates relatively high structure resistivity, retaining a high degree of its parent specific surface area. Robustness of the 3D framework enables a slow degradation process, resulting in controllable release of bioactive components, as confirmed by kinetic studies. BioNICS-1 can thus be considered as a suitable candidate for the design of a small drug molecule delivery system, which was demonstrated by successful loading and release of urea-a model drug for topical application-within and from the MOF pores.