Nutrient competition predicts gut microbiome restructuring under drug perturbations

2025/11/01 by Handuo Shi, Daniel Newton, Daniel P. Newton +10 · 1 voice
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Social Sciences · #Evolutionary Game Theory and Cooperation #Gut microbiota and health #Insect symbiosis and bacterial influences

paper · doi:10.1016/j.cell.2025.10.038

crossref issued 2025/11/01 · crossref published 2025/11/01 · crossref published-print 2025/11/01 · openalex publication_date 2025/11/01 · openalex created_date 2025/11/17 · crossref created 2025/11/17 · crossref deposited 2025/11/27 · crossref indexed 2026/07/14 · openalex updated_date 2026/08/01

Citations

• The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
• Antibiotic use and its consequences for the normal microbiome
• Emergence of community behaviors in the gut microbiota upon drug treatment
• NCBI BLAST: a better web interface
• Dependency on Medium and Temperature of Cell Size and Chemical Composition during Balanced Growth of Salmonella typhimurium
• Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering

Discussions

• Shi et al. screened 707 drugs on gut-derived communities and found that nutrient competition plays a key role in how drugs reshape microbiomes. Great resource from Kerwyn Casey Huang and colleagues in [bsky, 4 points, 0 comments]