2025/12/19 by Sherif Elmitwalli, John Mehegan, Sophie Braznell +1 · 1 voice
Social Sciences · Pharmacology, Toxicology and Pharmaceutics · Computer Science · #Misinformation and Its Impacts #Pharmacovigilance and Adverse Drug Reactions #Explainable Artificial Intelligence (XAI)
paper · pdf · doi:10.3389/frai.2025.1659861
openalex publication_date 2025/12/19 · openalex created_date 2025/12/19 · openalex updated_date 2026/07/23
Background: The proliferation of tobacco-related misinformation poses significant public health risks, requiring scalable solutions for credibility assessment. Traditional manual fact-checking approaches are resource-intensive and cannot match the pace of misinformation spread. Objective: To develop and validate a proof-of-concept multi-agent AI pipeline for automated credibility assessment of tobacco misinformation claims, evaluating its performance against expert human reviewers. Methods: We constructed a three-agent pipeline using OpenAI GPT-4.1 and the Crewai framework. The Serper API provided real-time evidence retrieval. The Content Analyzer classifies claims into four types: health impact, scientific assertion, policy, or statistical. The Scientific Fact Verifier queries authoritative sources (WHO, CDC, PubMed Central, Cochrane). The Health Evidence Assessor applies weighted scoring across five dimensions to assign 0-100 credibility scores on a five-level scale. Results: of 0.68 (95% CI: 0.52-0.84) indicating substantial agreement, 70% exact category agreement, 95% adjacent-level agreement, and processed each claim in under 7 s-over 1,000 × faster than manual review. Limitations: = 0.03) and did not classify any claims as "Highly Unlikely" despite expert assignment of two claims to this category. This proof-of-concept demonstrates technical feasibility and substantial inter-rater agreement while identifying areas for calibration in future large-scale implementations. Conclusion: Our proof-of-concept agentic AI pipeline demonstrates substantial agreement with expert assessments of tobacco-related claims while providing dramatic speed improvements. By combining zero-shot LLM reasoning, retrieval-grounded evidence verification, and a transparent five-level scoring schema, the system offers a practical tool for real-time misinformation monitoring in public health. This proof-of-concept establishes technical feasibility for automated tobacco misinformation assessment, with validation results supporting further development and larger-scale testing before operational deployment.