2026/07/15 by Lorenzo Posani, Shuqi Wang, Samuel P. Muscinelli +2 · 1 voice
Medicine · Neuroscience · #Cerebrospinal fluid and hydrocephalus #Epilepsy research and treatment #Neurological and metabolic disorders
paper · doi:10.1038/s41586-026-10668-4
openalex publication_date 2026/07/15 · openalex created_date 2026/07/16 · openalex updated_date 2026/07/29
A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently (categorical representations1–3) and the implications for neural computation. Here we systematically analysed how cortical neurons encode cognitive, sensory and movement variables across 43 cortical regions during a complex task (14,000+ units from the International Brain Laboratory public Brainwide Map dataset4) and studied how these properties change across the sensory–cognitive cortical hierarchy5. We found that the structure of the neural code was scale dependent. At the whole-cortex scale, neural selectivity was categorical and organized across regions in a way that reflected their anatomical connectivity. However, within individual regions, categorical representations were rare and limited to primary sensory areas, and neuronal responses were instead very diverse. With theoretical arguments and empirical evidence, we demonstrate that the diversity of neural responses enables high-dimensional representations and therefore high separability, allowing linear readouts to separate experimental conditions in many arbitrary ways. Indeed, when accounting for information that is actually encoded in each area, all cortical regions exhibit maximal separability. Our results indicate that cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations. Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.