The Liver X Receptor Axis Balances Intestinal Regeneration and Tumorigenesis

2024/01/01 · 1 voice
Medicine · #Helicobacter pylori-related gastroenterology studies #Liver Diseases and Immunity

paper · doi:10.1158/2159-8290.cd-rw2024-143

openalex publication_date 2024/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2025/12/27

Abstract

Major Finding: The liver X receptor (LXR) pathway drives intestinal regeneration and limits tumorigenesis.Concept: Transcriptomic and pharmacologic studies define a CYP27A1–LXR–TLS signaling axis in intestinal repair. Impact: This study delineates a critical node at the nexus between repair and tumorigenesis that may provide insights into mechanisms of controlled regeneration and underpin human colorectal cancer etiology.

Discussions

• Thanks Cancer Discovery Journal, @AACR for highlighting our recently published work @natureportfolio.bsky.social!!! The Liver X Receptor Axis Balances Intestinal Regeneration and Tumorigenesis doi.or [bsky, 5 points, 0 comments]

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