The serotonergic psychedelic DOI impairs deviance detection in the auditory cortex

2024/12/27 by Max Horrocks, Jennifer L. Mohn, Santiago Jaramillo · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · Psychology · #Neurotransmitter Receptor Influence on Behavior #Nicotinic Acetylcholine Receptors Study #Psychedelics and Drug Studies

paper · doi:10.1152/jn.00411.2024

openalex publication_date 2024/12/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

The neural basis of perceptual distortions induced by psychedelics remains poorly understood. This study demonstrates that the serotonergic psychedelic DOI increases neural response variability and impairs deviance detection in the auditory cortex by reducing sensitivity to unexpected sounds. These findings provide new insights into how psychedelics disrupt sensory processing and alter the balance between bottom-up and top-down neural signaling, contributing to our understanding of altered perception in the psychedelic state.

Citations

• REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics
• The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas
• Psychedelics

Cited by

• Cellular mechanisms of serotonergic psychedelics - apical hypercontextualisation

Discussions

• Our paper on the effects of a serotonergic psychedelic on auditory processing is out in the Journal of Neurophysiology. The data show, among other things, a reduced response to unexpected sounds under [bsky, 5 points, 0 comments]

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