2025/02/03 by Chunling Blue Lan, Karine Auclair · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Catalytic Cross-Coupling Reactions #Chemical Reactions and Isotopes #Fluorine in Organic Chemistry
paper · doi:10.1002/ejoc.202401383
openalex publication_date 2025/02/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/14
Abstract 1,5,7‐Triazabicyclo[4.4.0]dec‐5‐ene (TBD) is a bicyclic guanidine with booming applications. Bearing both a sp 2 ‐hybridized nitrogen and an adjacent N−H bond, TBD is a multifunctional and versatile reagent that is able to promote a variety of organic transformations. Although advancements with TBD in the polymer field have been well reviewed and documented, summaries that focus on synthetic methodologies are scarce. This review intends to provide a concise overview of synthetic methods utilizing TBD published over the past two decades. Classified based on the primary function of TBD, diverse transformations are described, and reaction mechanisms are incorporated when necessary. Examples from various fields are covered, including methodology developments, natural product syntheses, medicinal chemistry applications, as well as industrial utilizations.