2025/01/01 by Zhen Mei, Jay S. Raval, Justin Arnall +7 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Hemoglobin structure and function #Heme Oxygenase-1 and Carbon Monoxide #Neonatal Health and Biochemistry
paper · doi:10.1097/mjt.0000000000001777
openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/10
CLINICAL FEATURES: Sickle cell patients may develop a multitude of antibodies and experience life-threatening events with transfusion such as hyperhemolysis syndrome or delayed hemolytic transfusion reaction. Further transfusion may not be possible in such cases. THERAPEUTIC CHALLENGE: When conventional blood products are not available for transfusion yet the patient requires additional oxygen-carrying support, artificial oxygen carriers may be required. However, there are no such FDA-approved products available. SOLUTION: Emergency investigational new drug applications for a polymerized hemoglobin-based oxygen carrier (HBOC-201, Hemopure) were completed, and Expanded Access use was granted for these patients. HBOC-201 is an investigational bovine hemoglobin-based oxygen carrier. Herein, we report how acute resuscitation with HBOC-201 was potentially life saving while waiting for supportive therapy, erythropoietin, and/or immune modulatory drugs to take effect in all 3 patients.