Dopaminergic basis of salience dysregulation in psychosis

2014/01/02 by Toby T. Winton-Brown, Toby Winton‐Brown, Paolo Fusar-Poli +4 · 1 voice · 1 citation
Medicine · Neuroscience · Psychology · #Functional Brain Connectivity Studies #Obsessive-Compulsive Spectrum Disorders #Schizophrenia research and treatment

paper · doi:10.1016/j.tins.2013.11.003

openalex publication_date 2014/01/02 · crossref created 2014/01/02 · crossref issued 2014/02/01 · crossref published 2014/02/01 · crossref published-print 2014/02/01 · crossref deposited 2025/05/01 · openalex created_date 2025/10/10 · crossref indexed 2026/05/15 · openalex updated_date 2026/07/28

Citations

• Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia
• Predictive Reward Signal of Dopamine Neurons

Cited by

• Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition

Discussions

• That's a really interesting hypothesis! We think norepinephrine drives the arousal boost and dopamine drives the salience boost. Whether high levels of dopamine cause psychosis through the salience ne [bsky, 5 points, 0 comments]