APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease

2025/03/19 by Zonghua Li, Yuka A. Martens, Yingxue Ren +33 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Alzheimer's disease research and treatments #Genetics, Aging, and Longevity in Model Organisms #Nuclear Receptors and Signaling

paper · doi:10.1016/j.neuron.2025.02.017

openalex publication_date 2025/03/19 · crossref created 2025/03/19 · crossref issued 2025/05/01 · crossref published 2025/05/01 · crossref published-print 2025/05/01 · crossref deposited 2025/07/22 · openalex created_date 2025/10/10 · crossref indexed 2026/07/13 · openalex updated_date 2026/07/22

Citations

• Synaptic degeneration in Alzheimer’s disease
• Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
• Astrocyte Crosstalk in CNS Inflammation
• Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
• clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
• Lecanemab in Early Alzheimer’s Disease
• Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte‐derived lipid transport
• Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
• Human microglial state dynamics in Alzheimer’s disease progression

Cited by

• ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner

Discussions

• Learning more about APOE differences in the cell types of the brain 🧠 I presented "APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease" from @zhaonaa.bsky.socia [bsky, 5 points, 0 comments]