Chemical biology approaches to resolve the subcellular GPCR signaling landscape

2025/06/02 by Andreas Bock, Andreas Böck, Braden T. Lobingier +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Monoclonal and Polyclonal Antibodies Research #Neuropeptides and Animal Physiology #Receptor Mechanisms and Signaling

paper · doi:10.1038/s41589-025-01928-x

crossref issued 2025/06/02 · crossref published 2025/06/02 · crossref published-online 2025/06/02 · openalex publication_date 2025/06/02 · crossref created 2025/06/02 · crossref published-print 2025/08/01 · crossref deposited 2025/09/06 · openalex created_date 2025/10/10 · crossref indexed 2026/07/16 · openalex updated_date 2026/07/23

Citations

• G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?
• Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions
• Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals

Discussions

• Check out our later take on GPCR signaling in space and time and the toolbox of chemogenetic and chemical biology approaches to explore this cool phenomenon ⬇️. I had a blast working with my colleagu [bsky, 5 points, 0 comments]