Targeting protein disorder: the next hurdle in drug discovery

2025/06/09 by Tamás Lázár, Tamas Lazar, Acadia Connor +4 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · #Protein Degradation and Inhibitors #Protein Structure and Dynamics #Ubiquitin and proteasome pathways

paper · doi:10.1038/s41573-025-01220-6

crossref issued 2025/06/09 · crossref published 2025/06/09 · crossref published-online 2025/06/09 · openalex publication_date 2025/06/09 · crossref created 2025/06/09 · crossref deposited 2025/09/30 · crossref published-print 2025/10/01 · openalex created_date 2025/10/10 · crossref indexed 2026/07/22 · openalex updated_date 2026/07/29

Citations

• AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
• Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
• Natural products in drug discovery: advances and opportunities
• Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
• Highly accurate protein structure prediction with AlphaFold
• PROTAC targeted protein degraders: the past is prologue
• Harnessing protein folding neural networks for peptide–protein docking
• Advances in covalent drug discovery
• Conformational ensembles of the human intrinsically disordered proteome
• Accurate structure prediction of biomolecular interactions with AlphaFold 3

Cited by

• Why are there no clinically-approved drugs targeting disordered proteins?

Discussions

• 🚨 New Review in @natrevdrugdiscov.nature.com! We reviewed how to #drug intrinsically disordered proteins ( #IDPs) 🧬 Among many others, we touch upon: 🧪 IDP modulators (i-mods) in clinical trials; [bsky, 5 points, 1 comments]