2025/10/02 by Mehmet Kanbay, Laşin Özbek, Mustafa Güldan +4 · 2 voices
Immunology and Microbiology · Medicine · #Complement system in diseases #Neurological Complications and Syndromes #Renal Transplantation Outcomes and Treatments
paper · pdf · doi:10.1093/ndt/gfaf206
openalex publication_date 2025/10/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Long-term graft survival remains a challenge in kidney transplantation and, due to scarcity of available organs, solutions such as xenotransplantation have been revived, and testing of new agents, including complement-targeting biologicals with potential to improve transplant outcomes, has been enhanced. The complement system plays a critical role in the reaction of the host's immune system to the transplanted foreign kidney. Activation of the complement system is strongly involved in ischemia/reperfusion-mediated injury and rejection of allografts as well as xenografts, and post-transplant recurrence rates are high in kidney diseases linked to complement system dysregulation. Therefore, the precise understanding of the complement activation cascade is important for the development of successful strategies that target complement before and after transplantation. This article compiles the current knowledge on the role of the complement system in kidney transplantation, examines recent developments in the clinical use of complement-targeting therapeutics and discusses the limitations of these approaches. While the current study results indicate that complement-targeting strategies are still in their early stages, promising findings related to the discovery of new agents encourage the redesign of existing therapeutic approaches and the development of more effective treatments.