Engineering seed-specific gossypol-free cotton for human-safe consumption by harnessing the dominant-negative effect of the Gl2e mutation

2025/12/03 by Xiangfei Cheng, P. Wang, Xinchun Wang +18 · 1 voice
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Research in Cotton Cultivation #Lipid metabolism and biosynthesis #Plant Micronutrient Interactions and Effects

paper · doi:10.1016/j.xplc.2025.101628

openalex created_date 2025/12/03 · openalex publication_date 2025/12/03 · openalex updated_date 2026/07/26

Abstract

expression specifically during seed development, effectively suppressing gossypol gland formation in seeds. Multi-year, multi-location field trials of the SSGF cotton confirmed the stable production of gossypol-free seeds without compromising fiber yield or other key agronomic traits. Notably, completely gossypol-free oil and flour can be produced directly from SSGF seeds without the need for degossypolization. This work establishes a mechanistic foundation for understanding gland development and offers a sustainable path toward enhancing global plant-derived protein and oil resources.

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