2026/03/19 by Eduardo Rial-Rodríguez, Florian L. Wagner, Thomas Fuchß +5 · 1 voice
Chemistry · Energy · #CO2 Reduction Techniques and Catalysts #Electrochemical Analysis and Applications #Radical Photochemical Reactions
paper · doi:10.1016/j.chempr.2026.102952
openalex publication_date 2026/03/19 · openalex created_date 2026/03/20 · openalex updated_date 2026/07/22
The implementation of closed-loop automation in electrochemistry has been limited by engineering and chemical difficulties, especially when applied to the synthesis of densely functionalized molecules. To overcome these issues, we developed a modular autonomous platform integrating Bayesian optimization and online analysis. The versatility of the system was demonstrated in three different case studies, including a nickel-catalyzed C–N cross-coupling, an anodic modification of an amino acid, and a decarboxylative alkylation of a natural product. These reactions were optimized by considering a broad range of chemical inputs, translated into different continuous and categorical variables, toward the optimization of single or multiple objectives. Furthermore, the automation of anodic reactions was achieved by implementing a gas release module. Finally, the desired products were isolated by translating the slug conditions into continuous flow.