2025/02/01 by Sebastian Ocklenburg, Annakarina Mundorf, Jutta Peterburs +1 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Congenital heart defects research #Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities #Hemispheric Asymmetry in Neuroscience
paper · doi:10.1016/j.tig.2025.01.006
openalex publication_date 2025/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Handedness (i.e., the preference to use either the left or the right hand for fine motor tasks) is a widely investigated trait. Handedness heritability is consistently estimated to be 25%. After decades of research, recent large-scale genome-wide association and exome sequencing studies have identified multiple genes associated with handedness and highlighted tubulin genes. Tubulin genes play a role in several processes during brain development that may be relevant for handedness ontogenesis, including axon guidance, axon growth, and forming the inner structure of motile cilia. Moreover, tubulin genes are associated with several psychiatric disorders. This finding therefore may offer insights into biological pathways mediating the link between handedness, brain asymmetries, and psychiatric traits.