2019/03/23 by María del Pilar Navarrete-Meneses, Patricia Pérez-Vera, Patricia Pérez‐Vera
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Medicine · #Acute Lymphoblastic Leukemia research #Carcinogens and Genotoxicity Assessment #Pesticide Exposure and Toxicity
paper · doi:10.1515/reveh-2018-0070
crossref issued 2019/03/23 · crossref published 2019/03/23 · crossref published-online 2019/03/23 · openalex publication_date 2019/03/23 · crossref created 2019/03/23 · crossref published-print 2019/06/26 · crossref deposited 2021/04/22 · openalex created_date 2025/10/10 · crossref indexed 2026/07/24 · openalex updated_date 2026/07/30
Pyrethroid insecticides are commonly used worldwide. The chronic effects of these compounds are of concern given that epidemiological studies have suggested an association with hematological cancer, particularly in children. However, the biological evidence at molecular and cellular levels is limited. A review on the molecular and cellular effects of pyrethroids is helpful to guide the study of the biological plausibility of the association of pyrethroids with hematological cancer. We reviewed studies suggesting that pyrethroids are genotoxic, induce genetic rearrangements, alter gene expression and modify DNA. All of these biological modifications could potentially contribute to the carcinogenic process in hematopoietic cells.