2023/07/01 by Sohaib Kureshi, Sohaib A. Kureshi, Caroline Stowe +3
Medicine · Neuroscience · #Cerebrospinal fluid and hydrocephalus #Traumatic Brain Injury Research #Traumatic Brain Injury and Neurovascular Disturbances
paper · pdf · doi:10.1177/00368504231189536
crossref issued 2023/07/01 · crossref published 2023/07/01 · crossref published-print 2023/07/01 · openalex publication_date 2023/07/01 · crossref published-online 2023/07/27 · crossref created 2023/07/27 · openalex created_date 2025/10/10 · crossref deposited 2026/05/01 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31
There are two primary threats to the brain after concussion. The first is a buildup of neurotoxic proteins in the brain. The second, a partial consequence of the first, is a sustained neuroinflammatory response that may lead to central sensitization and the development of persistent post-concussive symptoms. These threats make neurotoxin clearance a high clinical priority in the acute period after injury. The glymphatic system is the brain's primary mechanism for clearing neurotoxic waste. The glymphatic system is intimately tied to the sleep cycle and circadian dynamics. However, glymphatic dysfunction and sleep disturbances are nearly ubiquitous in the acute period after concussion injury. Because of this, sleep optimization via circadian therapy is a time-sensitive and critical tool in acute concussion management.