2016/04/26 by M. Torres, Josep Pastor, J. Pastor +11
Medicine · Veterinary · #Gout, Hyperuricemia, Uric Acid #Research on Leishmaniasis Studies #Veterinary Medicine and Surgery
paper · doi:10.1111/jsap.12484
crossref issued 2016/04/26 · crossref published 2016/04/26 · crossref published-online 2016/04/26 · openalex publication_date 2016/04/26 · crossref created 2016/04/27 · crossref published-print 2016/06/01 · crossref deposited 2024/06/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21 · crossref indexed 2026/07/28
OBJECTIVE: The objective of this study was to describe the adverse effects of allopurinol on the urinary system during treatment of canine leishmaniasis. METHODS: Retrospective case series of 42 dogs that developed xanthinuria while receiving allopurinol treatment for leishmaniasis. RESULTS: Of 320 dogs diagnosed with leishmaniasis, 42 (13%) developed adverse urinary effects. Thirteen (of 42) dogs (31%) developed xanthinuria, renal mineralisation and urolithiasis; 11 (26·2%) showed xanthinuria with renal mineralisation; 9 (21·4%) had xanthinuria with urolithiasis and 9 (21·4%) developed xanthinuria alone. Urinary clinical signs developed in 19 dogs (45·2%). CLINICAL SIGNIFICANCE: This study demonstrates that urolithiasis and renal mineralisation can occur in dogs receiving allopurinol therapy. Dogs receiving therapy should be monitored for the development of urinary adverse effects from the beginning of treatment.