Retinol‐Augmented PRF Versus PRF Alone in Periodontal Regeneration: A Randomized Clinical Trial

2025/05/21 by Abdallah Hassan, Weam Elbattawy, Dalia Sanaa +6 · 1 citation
Dentistry · #Dental Erosion and Treatment #Dental Health and Care Utilization #Oral microbiology and periodontitis research

paper · pdf · doi:10.1111/jre.13404

crossref issued 2025/05/21 · crossref published 2025/05/21 · crossref published-online 2025/05/21 · openalex publication_date 2025/05/21 · crossref created 2025/05/22 · openalex created_date 2025/05/23 · crossref published-print 2025/08/01 · crossref deposited 2025/10/13 · crossref indexed 2026/07/29 · openalex updated_date 2026/07/30

Abstract

VitA/i-PRF and i-PRF alone improved clinical and radiographic outcomes of M-MIST in periodontal intraosseous defects of patients with stage-III grade B periodontitis. VitA/i-PRF showed a minor, clinically non-significant advantage in defect depth reduction and bone fill at 6 months, with effects diminishing by 9 months in patients with stage-III grade B periodontitis.

Citations

• Autogenous platelet concentrates for treatment of intrabony defects—A systematic review with meta‐analysis
• Can vitamins improve periodontal wound healing/regeneration?
• Retinol/inflammation affect stemness and differentiation potential of gingival stem/progenitor cells via Wnt/β‐catenin

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