Modeling network dynamics: the lac operon, a case study

2004/11/17 by J. M. G. Vilar, C. C. Guet, S. Leibler
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #q-bio.MN #cond-mat.stat-mech #physics.bio-ph #q-bio.CB

paper · pdf

published as J. Cell Biol. 161, 471-476 (2003)

arxiv created 2004/11/17 · arxiv updated 2009/12/01

Abstract

We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description -molecular, cellular, and that of cell population- into a single model, which seems to capture many experimental aspects of the system.

Related

• Study of the structure and dynamics of complex biological networks
• Multicellular control of gene networks
• Modeling biological networks: from single gene systems to large microbial communities
• Dynamic modeling of gene expression in prokaryotes: application to glucose-lactose diauxie in Escherichia coli
• Synchrony in a Boolean network model of the L-arabinose operon in Escherichia coli