2020/05/21 by Julia Kaźmierczak-Barańska, Karolina Boguszewska, Angelika A. Adamus-Grabicka +1 · 2 citations
Materials Science · Medicine · Nursing · #Nanoparticles: synthesis and applications #Vitamin C and Antioxidants Research #Vitamin D Research Studies
paper · pdf · doi:10.3390/nu12051501
openalex publication_date 2020/05/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results indicate its multi-directional cellular effects. Vitamin C, which belongs to antioxidants scavenging free radicals, also has a 'second face'-as a pro-oxidative factor. However, whether is the latter nature a defect harmful to the cell, or whether a virtue that is a source of benefit? In this review, we discuss the effects of vitamin C treatment in cancer prevention and the role of ascorbate in maintaining redox balance in the central nervous system (CNS). Finally, we discuss the effect of vitamin C supplementation on biomarkers of oxidative DNA damage and review the evidence that vitamin C has radioprotective properties.